Her father, a Murle chief and military commander within the Sudan People’s Liberation Movement/Army (SPLM/A) was killed in 1989. After her father’s death, she and her family spent a number of years in displaced camps in Sudan and refugee camps in Ethiopia to avoid conflicts of the war.
It’s through humanitarian work that Mary found her passion – helping others. Mary uses her exceptional talents in music to shed light on issues and calls for peace and reconciliation among her people. In 2005 she founded ABONA International, a nonprofit organization aimed supporting peace throughout South Sudan and providing assistance to girls and young women in violent and destructive situations.In 2007 she began work on her first music project, “Referendum”.
In January 2010, Mary was nominated by members of the Murle community to run for a parliamentary seat in the Southern Sudan Legislative Assembly in Juba. She campaigned for the elections that took place in April, 2010. 
Zooz, a song off of Mary Boyoi’s yet to be released second album was featured on Sudan Votes Music Hopes in March 2010. Sudan Votes Music Hopes is a collaboration of artists from across Sudan that wrote election songs “to encourage the people of Sudan to make a mark on their future”. The SVMH album was compiled by German singer songwriter Max Herre and is being distributed across Sudan on audio cassettes, radio and digitally via sudanvotes.com. The production was realized by Media in Cooperation and Transition (MICT) and was financed by the German Foreign Office. In August 2012, the Süd Electronic label released a vinyl with house remixes by Tama Sumo and Portable.